Beta Amyloid (1-42) Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-acid

Description

Main component of amyloid plaque found in the brain of patients with Alzheimer's disease.

Aβ is formed from the cleavage of APP (Amyloid Precursor Protein), a large transmembrane protein. Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in Alzheimer's Disease. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.


Beta Amyloid and related peptides

Beta Amyloid (1-42) Human 0.1mg

£150.00
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Beta Amyloid (1-42) Human 0.5mg

£200.00
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Beta Amyloid (1-42) Human 1mg

£300.00
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Catalogue number crb1000088
CAS 107761-42-2
Sequence (one letter code) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-acid
Sequence (three letter code) H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Research Area Neurodegenerative diseases (Alzheimer)
Purity >95%
Storage - 20 ° C
Molecular Weight 4514.04
Citations Younan, N., Chen, K., Rose, R., Crowther, D. and Viles, J. (2018). Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer disease. Journal of Biological Chemistry, pp.jbc.RA118.003319.
Main component of amyloid plaque found in the brain of patients with Alzheimer's disease.