Phosphorylated LRRKtide RLGRDKYK-[pT]-LRQIRQ-amide

Description

Substrate for the leucine-rich repeat kinase 2 (LRRK2) with phosphorylated threonine residue.
LRRKtide (also called moesin) is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM proteins: Ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553). These proteins influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. This peptide contains the phosphorylated threonine residue.

LRRK2 is a large, ubiquitous protein of unknown function. LRRK2 has GTPase and kinase activity, and is located in multiple areas of the cell, associated with intracellular membranes and vesicular structures; suggesting LRRK2 may be involved in several cellular pathways. LRRK2 is also found in most organs and mutations in LRRK2 have been identified in Parkinson’s disease.

Phosphorylated LRRKtide 0.5mg

£100.00
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Phosphorylated LRRKtide 1mg

£125.00
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Catalogue number crb1000466
Sequence (one letter code) RLGRDKYK-[pT]-LRQIRQ-amide
Sequence (three letter code) H-Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-[pThr]-Leu-Arg-Gln-Ile-Arg-Gln-NH2, Where [pThr] is phospho Threonine
Aliases ERM peptide, ERMtide, Leucine-Rich Repeat Kinase substrate, Moesin
Purity >95%
Molecular Weight 2009.1
Substrate for the leucine-rich repeat kinase 2 (LRRK2) with phosphorylated threonine residue.