LL-37 acid LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-acid

Description

Broad-spectrum anti-microbial activity. Produced in human epithelial cells
LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37, this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also regulates many aspects of the innate immune system and overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis, making LL-37 the most studied form of the human cathelicidin peptides.

LL-37 acid 0.5mg

£150.00
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LL-37 acid 1mg

£200.00
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Catalogue number crb1000007
Sequence (one letter code) LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-acid
Sequence (three letter code) H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
Aliases hCAP18
Purity >95%
Storage - 20 ° C
Molecular Weight 4493.3
References Singh, D., Vaughan, R. and Kao, C. (2014). LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH. J of Biol Chem, 289(40), 27614-27624. PMID: 25092290 Tripathi, S., Verma, A., Kim, E., White, M. and Hartshorn, K. (2014). LL-37 modulates human neutrophil responses to influenza A virus. J of Leukoc Biol, 96(5), 931-938. PMID: 25082153
Broad-spectrum anti-microbial activity. Produced in human epithelial cells