Teduglutide (GLP2 2G) HGDGSFSDEMNTILDNLAARDFIN-W-LIQTKITD-acid

Description

Teduglutide,is an analogue of GLP-2 and resistant to peptidase degradation. Enhanced biological activity relative to native GLP-2

Application Data

Teduglutide is a GLP-2 analogue, in which the alanine at position 2 has been substituted with glycine making the peptide resistant to degradation by dipeptidyl peptidase-4 (DPP-4). Teduglutide therefore has a longer half-life than GLP-2 (2-3 hours for Teduglutide vs 7 min for GLP-2). Teduglutide has high bioavailability after subcutaneous administration, suggesting that teduglutide has enhanced biological activity, relative to native GLP-2.
GLP-2 is a gut hormone produced in the enteroendocrine L cells of gastrointestinal tract by the cleavage of the 160-amino-acid proglucagon molecule. GLP-2 is secreted following the ingestion of food and carries out its activities via the GLP-2 G-protein coupled receptors (GLP-2Rs).
GLP-2 has a range of roles within the cell, including: anti-inflammatory effects; promoting the expansion of the intestinal mucosa; stimulating intestinal blood flow; inhibiting gastric acid secretion and gastric emptying; increasing intestinal barrier function and enhancing nutrient and fluid absorption

Teduglutide (GLP2 2G) 0.5mg

£150.00
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Teduglutide (GLP2 2G) 1mg

£200.00
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Catalogue number crb1000390
Sequence (one letter code) HGDGSFSDEMNTILDNLAARDFIN-W-LIQTKITD-acid
Sequence (three letter code) H-His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH
Purity >95%
Molecular Weight 3749.8
Teduglutide,is an analogue of GLP-2 and resistant to peptidase degradation. Enhanced biological activity relative to native GLP-2