ACTH (7-38) Human FRWGKPVGKKRRPVKVYPNGAEDESAEAFPLE-acid

Description

Fragment of human adrenocorticotropic hormone, a tropic hormone produced and secreted by the anterior pituitary gland.

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Catalogue number crb1000078
Sequence (one letter code) FRWGKPVGKKRRPVKVYPNGAEDESAEAFPLE-acid
Sequence (three letter code) H-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-OH
Purity >95%
Storage - 20 ° C
Molecular Weight 3659.11
References

Ghaddhab et al (2017) From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective. Front. Endocrinol. (Lausanne) 8 PMID: 28228747

Iwayama et al (2018) Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review. BMC Endocr. Disord. 18(1) PMID: 29587720

Kapas et al (1996) Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137(8) 3291 PMID: 8754753

Segment 7-38 of adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex

ACTH (7-38) Human

Cat No. Pack Size Price Qty

crb1000078h

0.5mg

$225.00

crb1000078j

1mg

$300.00