[5-FAM] EGFR/kinKDR peptide substrate [5-FAM]-EEPLYWSFPAKKK-amide


Peptide substrate of epidermal growth factor receptor (EGFR), which when dysregulated can contribute towards many diseases including cancer. Contains N-terminal green fluorescent tag.

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Catalogue number crb1101428
Sequence (one letter code) [5-FAM]-EEPLYWSFPAKKK-amide
Sequence (three letter code) [5-FAM]-Glu-Glu-Pro-Leu-Tyr-Trp-Ser-Phe-Pro-Ala-Lys-Lys-Lys-NH2
Purity >95%
Molecular Weight 1978.9

Wieduwilt and Moasser (2011) The epidermal growth factor receptor family: Biology driving targeted therapeutics. Cell Mol. Life Sci. 65(10) 1566 PMID: 18259690


Xie et al (2011) AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo. PLoS One 6(7)  e21487 PMID: 21789172


Rudolf (2014) A Comparison of Protein Kinases Inhibitor Screening Methods Using Both Enzymatic Activity and Binding Affinity Determination.  PLOS One 9(6) e98800. PMID: 24915177

Peptide substrate of the epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family known as ErbBs or HER receptors. These receptors are involved in the regulation of cell proliferation, survival, differentiation and migration. When these receptors are dysregulated many diseases, including cancer, can arise.

Binding to the ligand binding domain of the EGFR causes receptor dimerization. This is sequentially followed by the tyrosine kinase domain being activated and the tyrosine residues on the C-terminal tail of the receptor becoming phosphorylated, activating downstream signalling pathways.

This peptide contains an N-terminal 5-Carboxyfluorescein (5-FAM) moiety, a widely used green fluorescent tag.

[5-FAM] EGFR/kinKDR peptide substrate

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