[5-FAM]-Galanin (1-30) Human is a neuropeptide released by the locus coeruleus with neuroprotective properties. It contains 5-Carboxyfluorescein (5-FAM), a widely used, green fluorescent tag.
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Weinshenker and Holmes (2016) Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin. Brain Res. 1641 320.
Laque et al (2013) Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. Am. J. Physiol-Endocrinol. Metab. 304(9) E999-E1011
Galanin is a neuropeptide synthesised and released by the brainstem locus coeruleus (LC). Galanin is expressed in most LC neurons in rodent and human and has been shown to inhibit LC activity by hyperpolarising LC neurons, suppressing their spontaneous firing rate, and enhancing α2-adrenergic receptor-mediated negative feedback. Galanin is also a potent trophic and neuroprotective factor throughout the nervous system.
Galanin protects against a variety of physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied in relation to Alzheimer’s disease and galaninergic neurons have been shown to be spared in late stage Alzheimer’s relative to non-galaninergic neurones.
[5-FAM]-Galanin (1-30) Human contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
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