[5-FAM]-IFN-γ receptor (pTyr) peptide [5-FAM]-G-[pY]-DKPH-V-L-amide

Description

Signal transducers and activators of transcription 1 (STAT1) binding peptide with a phosphorylated tyrosine residue and an N-terminal 5-FAM, a widely used green fluorescent tag

See full description

Catalogue number crb1100416
Sequence (one letter code) [5-FAM]-G-[pY]-DKPH-V-L-amide
Sequence (three letter code) Gly-[pTyr]-Asp-Lys-Pro-His-Val-Leu-NH2
Purity >95%
Storage -20°C
Molecular Weight 1364.5
References

Green, D., Young, H. and Valencia, J. (2017). Current prospects of type II interferon γ signaling and autoimmunity. J Biol Chem, 292(34), 13925-13933. PMID: 28652404

Signal transducers and activators of transcription 1 (STAT1) binding peptide. STAT1 is a biotinylated protein that contains an SH2 domain, which binds to specific phospho (pY)-containing peptide motifs. Interferon γ (IFNγ/type II IFN) activates STAT1 by its phosphorylation. STAT1 is a critical mediator of cytokine signalling and has been reported as a tumour suppressor in breast cancer, myeloma and leukaemia.


IFNγ is secreted by immune cells and signals through the IFNγ receptor and downstream signalling pathways including the janus kinase (JAK)/STAT pathway. IFNγ is a central mediator of the adaptive immune system and regulates macrophage activation to promote the expression of high levels of pro-inflammatory cytokines (Il-1β, IL-12, IL-23, and TNF-α); production of reactive nitrogen and oxygen intermediates; promotion of CD4+ T helper 1 (Th1) cell response and strong inflammatory activity. IFNγ inhibits viral replication and is essential for vaccine-mediated immune responses. IFNγ signalling is usually short-lived to elicit recovery of homeostasis, including tissue repair, however IFN-γ is elevated in severe adult asthma and is present in the airways of children with severe asthma. This indicates a key role for IFNγ in inflammatory conditions.


Peptide contains a phosphorylated tyrosine residue and an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag

[5-FAM]-IFN-γ receptor (pTyr) peptide

Cat No. Pack Size Price Qty

crb1100416f

0.1mg

$112.50

crb1100416h

0.5mg

$150.00