α-CGRP (mouse, rat) SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-amide

Description

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion.

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Catalogue number crb1000889
CAS 96827-03-1
Sequence (one letter code) SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-amide
Sequence (three letter code) H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
Modifications Disulfide bridge Cys2 - Cys7
Aliases a-Calcitonin gene-related peptide (mouse, rat)
Purity >95%
Storage -20°C
Molecular Weight 3803.9
References

Nakamura et al (1998) Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res. 807 203 PMID: 9757038

Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616

Salim et al (1998) Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca2+ mobilization at mouse muscle endplates. Br.J.Pharmacol. 125 277 PMID: 9786499

 

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion.  It also has a function in temperature homeostasis, increases heart rate, and can play a role in the release of the pituitary hormone.

α-CGRP (mouse, rat)

Cat No. Pack Size Price Qty

crb1000889h

α-CGRP Mouse, Rat 0.5mg

$262.50

crb1000889j

α-CGRP Mouse, Rat 1mg

$450.00