Beta Amyloid (1-40) Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-acid

Description

Key subunit of extracellular plaques found in the brains of patients with Alzheimer’s disease


Beta Amyloid and related peptides

See full description

Catalogue number crb1000087
CAS 131438-79-4
Sequence (one letter code) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-acid
Sequence (three letter code) H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
Aliases Abeta 1-40, Aβ 1-40
Research Area Central Nervous system, Neurodegenerative diseases (Alzheimer)
Purity >95%
Molecular Weight 4329.8
Citations Viles, J. et al (2019). Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy. Journal of Biological Chemistry, pp.jbc.AC118.007195. doi: 10.1074/jbc.AC118.007195
References

Ricciarelli, R. and Fedele, E. (2017). The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind. Curr Neuropharmacol, 15(6). PMID: 28093977

 

Selkoe, D. and Hardy, J. (2016). The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med, 8(6), 595-608. PMID: 27025652

 

Masters, C. and Selkoe, D. (2012). Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease. Cold Spring Harb Perspect Med, 2(6), a006262-a006262. PMID: 22675658 

Amino acids 1-40 of amyloid beta (Aβ), a major C terminal variant of amyloid beta and the most abundant Aβ peptide in the human brain. Aβ has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer’s disease (AD) and Down’s syndrome (DS) and has therefore been extensively studied as a potential target for treatment of AD. Aβ is formed from the cleavage of the large, transmembrane protein; APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce Aβ oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival

Beta Amyloid (1-40) Human

Cat No. Pack Size Price Qty

crb1000087f

0.1mg

$225.00

crb1000087h

0.5mg

$300.00

crb1000087j

1mg

$450.00