Beta Amyloid (1-40) Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-acid

Description

One of the main constituents of amyloid plaque linked to Alzheimer's disease. Shown to have both neurotrophic and neurotoxic effects. Peptide found in plaques in the brains of patients with Alzheimer's disease.

Aβ is formed from the cleavage of APP (Amyloid Precursor Protein), a large transmembrane protein. Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in Alzheimer's Disease. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.


Beta Amyloid and related peptides

Beta Amyloid (1-40) Human 0.1mg

£150.00
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Beta Amyloid (1-40) Human 0.5mg

£200.00
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Beta Amyloid (1-40) Human 1mg

£300.00
Datasheet download
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Catalogue number crb1000087
CAS 131438-79-4
Sequence (one letter code) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-acid
Sequence (three letter code) H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
Research Area Neurodegenerative diseases (Alzheimer)
Purity >95%
Molecular Weight 4329.8
One of the main constituents of amyloid plaque linked to Alzheimer's disease. Shown to have both neurotrophic and neurotoxic effects. Peptide found in plaques in the brains of patients with Alzheimer's disease.