Acetyl-alpha-MSH Heavy Acetyl-SYSMEH-[U-13C9,15N-Phe]-RWGKPV-amide


Non-selective agonist of melanocortin receptors involved in metabolic and immune homeostasis. Contains a phenylalanine residue labelled with 13C and 15N stable isotopes

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Catalogue number crb1301033
Sequence (one letter code) Acetyl-SYSMEH-[U-13C9,15N-Phe]-RWGKPV-amide
Sequence (three letter code) Acetyl-Ser-Tyr-Ser-Met-Glu-His-[U-13C9,15N-Phe]-Arg-Trp-Gly-Lys-Pro-Val-NH2
Research Area homeostasis and cardiovascular functions
Purity >95%
Storage -20°C
Molecular Weight 1673.8

Vecsernyes, M., Szokol, M., Bombicz, M., Priksz, D., Gesztelyi, R., Fulop, G., Varga, B., Juhasz, B., Haines, D. and Tosaki, A. (2017). Alpha–Melanocyte-stimulating Hormone Induces Vasodilation and Exerts Cardioprotection Through the Heme-Oxygenase Pathway in Rat Hearts. J Cardiovasc Pharmacol, 69(5), 286-297. PMID: 28195947

Taylor, A. (2013). Alpha-Melanocyte Stimulating Hormone (α-MSH) Is a Post-Caspase Suppressor of Apoptosis in RAW 264.7 Macrophages. PLoS ONE, 8(8), e74488. PMID:  24009773

Capsoni, F., Ongari, A., Lonati, C., Accetta, R., Gatti, S. and Catania, A. (2015). α-Melanocyte-stimulating-hormone (α-MSH) modulates human chondrocyte activation induced by proinflammatory cytokines. BMC Musculoskelet Disord, 16(1). PMID: 26093672

Alpha-melanocyte stimulating hormone (α-MSH) is a melanocortin family neuropeptide which plays important roles in metabolic and immune homeostasis. It is formed from the cleavage of adrenocorticotropic hormone, the cleavage product of proopiomelanocortin hormone. α-MSH is expressed ubiquitously to varying degrees in a wide variety of cells including the hypothalamus, monocytes and retinal pigment epithelial cells. α-MSH is a non-selective agonist of melanocortin receptors.

α-MSH is a suppresser of inflammation from both innate and adaptive immune pathways, it is involved in hair and skin pigmentation (through MC1 receptor activation), has reproductive functions, cardio protective functions and regulates food intake and energy metabolism.

The phenylalanine residue at position 7 of this peptide is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide. The N-terminal of the peptide is protected by an acetyl group

Acetyl-alpha-MSH Heavy

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