Adrenomedullin (22-52) TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-amide

Description

Amino acids 22 to 52 of free circulating CGRP super-family peptide involved in several diseased states including sepsis, heart failure and cancers

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Catalogue number crb1001438
Sequence (one letter code) TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-amide
Sequence (three letter code) H-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
Molecular Weight 3573.9
Research Area Cancer, Immunology, Metabolism, Microbiology, Regulated Cell Death
Purity >95%
Storage -20°C
References

Geven et al., (2018). Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis. Front Immunol9: 292. PMID: 29520277

 

Larráyoz et al., (2014). Adrenomedullin and tumour microenvironment. J Transl Med12: 339. PMID: 25475159

 

Voors et al., (2019). Adrenomedullin in heart failure: pathophysiology and therapeutic application. Eur J Heart Fail. 21(2): 163. PMID: 30592365

Adrenomedullin (ADM), is a free circulating peptide of the amylin/calcitonin gene-related peptide (CGRP) super-family. It is widely expressed in virtually all human tissues and is involved in regulation of endothelial barrier function; vascular tone; immunoregulation; cellular proliferation and apoptosis. ADM is implicated in the pathophysiology of several diseased states including: sepsis; heart failure; inflammatory bowel disease; diabetes; eye pathologies and many cancers. ADM levels are often increased during these diseased states often correlating with disease severity and mortality. ADM is therefore of interest as a target for these diseases. ADM also displays potent antimicrobial action against Gram-positive and Gram-negative bacteria.

The 52 amino acid ADM is produced by multiple cleavage steps from the original 85 amino acid long preprohormone (prepro-ADM). ADM exerts its effects by ligation of receptor complexes consisting of the calcitonin receptor-like receptor (CRLR) combined with a specific receptor activity-modifying protein (RAMP). Interaction of ADM with its receptor occurs through its C-terminal moiety.

Adrenomedullin (22-52)

Cat No. Pack Size Price Qty

crb1001438h

0.5mg

$165.00

crb1001438j

1mg

$330.00