Angiotensin II Heavy DRVY-[U-13C6,15N-Ile]-HPF-acid


Key peptide of the RAS, upregulated in metabolic disorders and cancers. Isoleucine residue labelled with stable 13C and 15N isotopes

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Catalogue number crb1300305
Sequence (one letter code) DRVY-[U-13C6,15N-Ile]-HPF-acid
Sequence (three letter code) H-Asp-Arg-Val-Tyr-[U-13C6,15N-Ile]-His-Pro-Phe-OH
Purity >95%
Storage -20°C
Molecular Weight 1052.5

Azevedo et al (2014) Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression. PLoS ONE 9(11) e110934 PMID: 25365520

Rodrigues-Ferreira et al (2012) Angiotensin II Facilitates Breast Cancer Cell Migration and Metastasis. PLoS ONE 7(4) e35667 PMID: 22536420

Takane et al (2017) Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure. J. Am. Heart Assoc. 6(4) e004897 PMID: 28428194

Angiotensin II (Ang-II) is a key signalling peptide of the renin angiotensin system (RAS) which is  involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and is widely studied in relation to lifestyle-related diseases. 

Ang-II is produced from angiotensinogen (AGT) via the intermediate angiotensin I (Ang-I). AGTis cleaved by the aspartyl-protease, renin, to produce Ang-I, which is then cleaved by the dicarboxyl-peptidase angiotensin converting enzyme (ACE), which removes a histidine and a leucine, from the C-terminus of Ang-I to form Ang-II.

Ang-II exerts its affect by binding to the G-protein-coupled receptors; Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors. Ang-II plays central roles in glucose metabolism and blood pressure. Increased levels of Ang-II have also been associated with Alzheimer’s disease, and certain cancers including oesophageal squamous cell carcinoma (ESCC), brain cancers and breast cancer. The effects of Ang-II appear to be supressed or limited by another branch of the RAS; the ACE2/Ang-(1-7)/Mas pathway.

The isoleucine residue at position 5 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide

Angiotensin II Heavy

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