Apolipoprotein B-100 (APOB100) (1108-1118) Heavy SEI-[U-13C6,15N-Leu]-AHWSPAK-acid


Amino acids 1108-1118 of apoB-100, a highly expressed protein involved in Lyme arthritis. Contains a leucine residue labelled with stable 13C and 15N isotopes

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Catalogue number crb1301564
Sequence (one letter code) SEI-[U-13C6,15N-Leu]-AHWSPAK-acid
Sequence (three letter code) H-Ser-Glu-Ile-[U-13C6,15N-Leu]-Ala-His-Trp-Ser-Pro-Ala-Lys-OH
Research Area Immunology
Purity >95%
Storage -20°C
Molecular Weight 1244.7

Crowley et al., (2015).  A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease. J Infect Dis. 212(11): 1841–1850. PMID: 26014802

Apolipoprotein B-100 (apoB-100) is a highly expressed human protein and a novel autoantigen, which is targeted by T- and B-cell immune responses in a subgroup of Lyme arthritis (LA) patients. ApoB-100 is present at high levels in the joint fluid of these patients. The high levels of apoB-100 in joints may lead to antigen presentation of apoB-100 peptides by human leukocyte antigen (HLA)–DR molecules, as well as to T- and B-cell responses to the protein. HLA-DR-presented peptides of apoB-100 have been shown to be immunoreactive.

Lyme arthritis (LA) is a late manifestation of infection with the tick-borne spirochete, Borrelia burgdorferi.

The leucine residue at position four of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.

Apolipoprotein B-100 (APOB100) (1108-1118) Heavy

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