Beta Amyloid (1-42) Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-acid

Description

Key subunit of extracellular plaques found in brains of patients with Alzheimer’s disease.

 


Amyloid β-protein (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer’s disease (AD) and Down’s syndrome.  Aβ has therefore been extensively studied as a potential target for treatment of AD.


 


Aβ is formed from the cleavage of the large, transmembrane protein; APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. 


 


Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival


Beta Amyloid and related peptides

Beta Amyloid (1-42) Human 0.1mg

$225.00
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Beta Amyloid (1-42) Human 0.5mg

$300.00
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Beta Amyloid (1-42) Human 1mg

$450.00
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Catalogue number crb1000088
CAS 107761-42-2
Sequence (one letter code) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-acid
Sequence (three letter code) H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Research Area Neurodegenerative diseases (Alzheimer)
Purity >95%
Storage - 20 ° C
Molecular Weight 4514.04
Citations Younan, N., Chen, K., Rose, R., Crowther, D. and Viles, J. (2018). Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer disease. Journal of Biological Chemistry, pp.jbc.RA118.003319.
References

Ricciarelli, R. and Fedele, E. (2017). The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind. Curr Neuropharmacol, 15(6). PMID: 28093977

Selkoe, D. and Hardy, J. (2016). The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med, 8(6), 595-608. PMID: 27025652

Pearson, H. and Peers, C. (2006). Physiological roles for amyloid β peptides. J Physiol, 575(1), 5-10. PMID: 16809372

Masters, C. and Selkoe, D. (2012). Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease. Cold Spring Harb Perspect Med, 2(6), a006262-a006262. PMID: 22675658

Key subunit of extracellular plaques found in brains of patients with Alzheimer’s disease.