Galanin (2-12) acid WTLNSAGYLLG-acid

Description

Neuropeptide and potent trophic and neuroprotective factor expressed throughout the nervous system

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Catalogue number crb1001306
Sequence (one letter code) WTLNSAGYLLG-acid
Sequence (three letter code) H-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-OH
Research Area Central Nervous system, Neurodegenerative diseases (Alzheimer)
Purity >95%
Storage -20°C
Molecular Weight 1193.6
Residues 2-12 of galanin peptide. Galanin is a neuropeptide synthesised and released by the brainstem locus coeruleus (LC). Galanin is expressed in most LC neurons in rodent and human and has been shown to inhibit LC activity by hyperpolarising LC neurons, suppressing their spontaneous firing rate, and enhancing α2-adrenergic receptor-mediated negative feedback. Galanin is also a potent trophic and neuroprotective factor throughout the nervous system.
Galanin protects against a variety of physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied in relation to Alzheimer’s disease and galaninergic neurons have been shown to be spared in late stage Alzheimer’s relative to non-galaninergic neurones.

Galanin (2-12) acid

Cat No. Pack Size Price Qty

crb1001306h

0.5mg

$112.50

crb1001306j

1mg

$150.00