Galantide GWTLNSAGYLLGPQQFFGLM-amide

Description

Galantide is a reversible and non-specific galanin receptor antagonist.  In vitro it dose dependently antagonizes galanin mediated inhibition of the glucose induced insulin secretion from mouse pancreatic islets.  In vivo intracerebroventricular injection of galanin inhibits sexual behavior in male rats without producing any other locomotor or behavioral deficit.  Galantide has been found to improve social memory in animal models.

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Catalogue number crb1001439
CAS 138579-66-5
Sequence (one letter code) GWTLNSAGYLLGPQQFFGLM-amide
Sequence (three letter code) H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Purity >95%
Storage -20°C
Molecular Weight 2198.1
References

Lindskog et al (1992) The novel high-affinity antagonist, galantide, blocks the galanin-mediatedinhibition of glucose-induced insulin secretion. Eur. J. Pharmacol. 1992 210(2) 183  Benelli et al (1994) Galantide stimulates sexual behaviour in male rats. Eur. J. Pharmacol. 260(2-3):279  Arletti et al (1997) Galantide improves social memory in rats. Pharmacol Res. 1997 35(4) 317

Galantide is a reversible and non-specific galanin receptor antagonist.  In vitro it dose dependently antagonizes galanin mediated inhibition of the glucose induced insulin secretion from mouse pancreatic islets.  In vivo intracerebroventricular injection of galanin inhibits sexual behavior in male rats without producing any other locomotor or behavioral deficit.  Galantide has been found to improve social memory in animal models.

Galantide

Cat No. Pack Size Price Qty

crb1001439h

0.5mg

$112.50

crb1001439j

1mg

$150.00