HER-2 substrate peptide GGMEDIYFEFMGGKKK-amide


Substrate for ErbB-2/HER-2 receptor tyrosine Kinase.
Human epidermal growth factor receptor 2 (HER-2)/Epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity, the receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3′-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays.

HER-2 substrate peptide 0.5mg

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HER-2 substrate peptide 1mg

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Catalogue number crb1000259
Sequence (one letter code) GGMEDIYFEFMGGKKK-amide
Sequence (three letter code) H-Gly-Gly-Met-Glu-Asp-Ile-Tyr-Phe-Glu-Phe-Met-Gly-Gly-Lys-Lys-Lys-NH2
Aliases HER2 substrate
Research Area Cancer
Purity >95%
Molecular Weight 1836.14
Substrate for ErbB-2/HER-2 receptor tyrosine Kinase.