HER-2 substrate peptide GGMEDIYFEFMGGKKK-amide

Description

Human epidermal growth factor receptor 2 (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity. The receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3′-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays.

Substrate for ErbB-2/HER-2 receptor tyrosine kinase

HER-2 substrate peptide 0.5mg

$112.50
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HER-2 substrate peptide 1mg

$150.00
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Catalogue number crb1000259
Sequence (one letter code) GGMEDIYFEFMGGKKK-amide
Sequence (three letter code) H-Gly-Gly-Met-Glu-Asp-Ile-Tyr-Phe-Glu-Phe-Met-Gly-Gly-Lys-Lys-Lys-NH2
Aliases HER2 substrate
Research Area Cancer
Purity >95%
Molecular Weight 1836.14
References

Muniyan, S., Chen, S., Lin, F., Wang, Z., Mehta, P., Batra, S. and Lin, M. (2015). ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells. Cell Signal, 27(11), 2261-2271. PMID: 26257301

Qiu, C., Tarrant, M., Choi, S., Sathyamurthy, A., Bose, R., Banjade, S., Pal, A., Bornmann, W., Lemmon, M., Cole, P. and Leahy, D. (2008). Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase. Structure, 16(3), 460-467. PMID: 18334220

Collier, T., Diraviyam, K., Monsey, J., Shen, W., Sept, D. and Bose, R. (2013). Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface. J Biol Chem, 288(35), 25254-25264. PMID: 23843458

Human epidermal growth factor receptor 2 (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity. The receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3′-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays.