Histone H1 derived peptide GGGPATPKKAKKL-acid


Peptide from the H1 linker histone

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Catalogue number crb1000934
Sequence (one letter code) GGGPATPKKAKKL-acid
Sequence (three letter code) H-Gly-Gly-Gly-Pro-Ala-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu-OH
Molecular Weight 1251.8
Purity >95%
Storage -20°C

Brockers and Schneider (2019). Histone H1, the forgotten histone. Epigenomics. 11 (4): 363–366

H1 is the linker histone and is important for chromatin condensation, it binds to the nucleosomal core particles and protects the free linker DNA (∼20 bp) between each nucleosome. H1 can fine-tune transcription in a locus-specific manner. H1 is involved in several processes, its interaction partners include: pre-mRNA splicing factors; histone chaperones; components of the transcription machinery and DNA-damage response factors.

There a 12 subtypes of the H1 linker histone, and they are thought to have specific functions, making H1 the most divergent histone protein family. Like other histones, H1's are extensively post-translationally modified with modifications including: methylation, acetylation, ubiquitination, formylation, poly-ADP ribosylation and phosphorylation.

Changes in H1 composition and expression levels are seen in several cancers and other diseases.

Histone H1 derived peptide

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