Histone H1 derived peptide GGGPATPKKAKKL-acid

Description

Peptide from the H1 linker histone

See full description

Catalogue number crb1000934
Sequence (one letter code) GGGPATPKKAKKL-acid
Sequence (three letter code) H-Gly-Gly-Gly-Pro-Ala-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu-OH
Molecular Weight 1251.8
Purity >95%
Storage -20°C
References

Brockers and Schneider (2019). Histone H1, the forgotten histone. Epigenomics. 11 (4): 363–366

H1 is the linker histone and is important for chromatin condensation, it binds to the nucleosomal core particles and protects the free linker DNA (∼20 bp) between each nucleosome. H1 can fine-tune transcription in a locus-specific manner. H1 is involved in several processes, its interaction partners include: pre-mRNA splicing factors; histone chaperones; components of the transcription machinery and DNA-damage response factors.

There a 12 subtypes of the H1 linker histone, and they are thought to have specific functions, making H1 the most divergent histone protein family. Like other histones, H1's are extensively post-translationally modified with modifications including: methylation, acetylation, ubiquitination, formylation, poly-ADP ribosylation and phosphorylation.

Changes in H1 composition and expression levels are seen in several cancers and other diseases.

Histone H1 derived peptide

Cat No. Pack Size Price Qty

crb1000934h

0.5mg

$127.50

crb1000934j

1mg

$165.00