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Akishiba and Futaki (2019) Inducible Membrane Permeabilization by Attenuated Lytic Peptides: A New Concept for Accessing Cell Interiors through Ruffled Membranes. Mol. Pharm. 16(6) 2540 https://doi.org/10.1021/acs.molpharmaceut.9b00156
L17E is a peptide which functions in the intracellular delivery of molecules through permeating the cell membrane. Structurally it features the cationic amphiphilic spider toxin peptide motif and at position 17 the leucine residue has been replaced with a glutamic acid.
L17E allows biomacromolecules to translocate to the cytosol. This occurs when the structure of the cell is altered when L17E promotes actin remodelling, micropinocytosis and membrane ruffling followed by membrane rupture. Furthermore L17E can aid in the delivery of antibodies into the cytosol.
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