Substrate for the leucine-rich repeat kinase 2 (LRRK2), derived from the sequences of the ERM proteins

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Catalogue number crb1000258
Sequence (one letter code) RLGRDKYKTLRQIRQ-amide
Sequence (three letter code) H-Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-Thr-Leu-Arg-Gln-Ile-Arg-Gln-NH2
Aliases ERM peptide, ERMtide, Leucine-Rich Repeat Kinase substrate, Moesin
Purity >95%
Storage -20°C
Molecular Weight 1929.1

Esteves, A., Swerdlow, R. and Cardoso, S. (2014). LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis. Exp Neurol, 261, 206-216. PMID: 24907399

Jaleel, M., Nichols, R., Deak, M., Campbell, D., Gillardon, F., Knebel, A. and Alessi, D. (2007). LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J, 405(2), 307-317. PMID: 17447891

LRRKtide (also called moesin) is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM proteins: Ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553). These proteins influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site.

LRRK2 is a large, ubiquitous protein of unknown function. LRRK2 has GTPase and kinase activity, and is located in multiple areas of the cell where it is found associated with intracellular membranes and vesicular structures. Its multiple cellular locations suggest that LRRK2 may be involved in several cellular pathways. LRRK2 is also found in most organs and mutations in LRRK2 have been identified in Parkinson’s disease

LRRKtide amide

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