MAP1A (169-178) Light LGIQAEPLYR-acid


Fragment of MAP1A, a structural protein essential for organising neuronal microtubules

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Catalogue number crb1001250
Sequence (one letter code) LGIQAEPLYR-acid
Sequence (three letter code) Leu-Gly-Ile-Gln-Ala-Glu-Pro-Leu-Tyr-Arg-OH
Aliases P78559, Microtubule-associated protein 1A
Purity >95%
Storage -20°C
Molecular Weight 1158.6

Liu, Y., Lee, J. and Ackerman, S. (2015). Mutations in the Microtubule-Associated Protein 1A (Map1a) Gene Cause Purkinje Cell Degeneration. J Neurosci, 35(11), 4587-4598. PMID: 25788676

Amino acids 169-178 of microtubule-associated protein 1A (MAP1A) light chain. MAP1A is expressed from the Map1a gene which encodes a precursor polypeptide which is cleaved to produce MAP1A heavy chain and light chain.

MAP1A is a structural protein essential for the organisation of neuronal microtubules (MTs) and is abundantly expressed in the mammalian brain. MAP1A is thought to help maintain the neuronal MT network, and modulate synaptic proteins and neuronal survival in the adult central nervous system (CNS). When MAP1A is disrupted in the body it results in problems in coordination, tremors, and late-onset degeneration of cerebellar Purkinje cells

MAP1A (169-178) Light

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