MHV EPTM LVLSPSIYLYDRSKQ-acid

Description

Post-transmembrane region (PTM) from the envelope protein (E) of the coronavirus Mouse Hepatitis Virus (MHV).

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Catalogue number crb1001523
Sequence (one letter code) LVLSPSIYLYDRSKQ-acid
Sequence (three letter code) H-Leu-Val-Leu-Ser-Pro-Ser-Ile-Tyr-Leu-Tyr-Asp-Arg-Ser-Lys-Gln-OH
Modifications Where lowercase indicates D-amino acids
Purity >95%
Storage -20°C
Molecular Weight 1781
References

Alsaadi et al., (2020). Identification of a Membrane Binding Peptide in the Envelope Protein of MHV Coronavirus. Viruses. 12(9): 1054. PMID: 32971895

Post-transmembrane region (PTM) from the envelope protein (E) of the coronavirus; Mouse Hepatitis Virus (MHV). This protein region is involved in direct membrane binding, with the C-terminal hydrophobic residues of this peptide, thought to be most relevant for membrane binding.

After replication, coronaviruses (CoVs) assemble on intracellular membranes, the coronavirus envelope protein (E) is involved in virus assembly and release. E proteins have been located in the endoplasmic reticulum Golgi intermediate compartment (ERGIC) and Golgi of infected cells but are not thought to traffic to the cell surface of infected cells.

CoV E is a small hydrophobic protein which is conserved between coronaviruses. E consist of a short hydrophilic amino terminal region, a hydrophobic transmembrane region and a carboxy-terminal region. CoV E protein is an integral membrane protein.

E has been considered a therapeutic target for SARS-CoV-2.

MHV EPTM

Cat No. Pack Size Price Qty

crb1001523h

0.5mg

$112.50

crb1001523j

1mg

$150.00