MOG (35-55) acid Mouse, Rat MEVGWYRSPFSRVVHLYRNGK-acid

Description

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation. MOG contains one extracellular domain, one transmembrane domain, one cytoplasmic loop, a membrane-associated region, and a cytoplasmic tail. It has been suggested that MOG may function as a cell surface receptor or cell adhesion molecule. Fifteen different alternatively spliced isoforms have been detected in humans which are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or can be found in a secreted form. The secreted form of MOG could have important effects in triggering autoimmunity if released into the cerebrospinal fluid and then drained into the periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases and is therefore widely studied in this field. The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing MS like symptoms in animal models. Contains a free carboxylic acid at the C-terminal
Myelin oligodendrocyte glycoprotein fragment. MOG (35-55) induces autoimmune encephalomyelitis in transgenic rodents.

MOG(35-55) acid Mouse, Rat 0.5mg

£75.00
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MOG(35-55) acid Mouse, Rat 1mg

£100.00
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MOG(35-55) acid Mouse, Rat 5mg

£150.00
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MOG(35-55) acid Mouse, Rat 10mg

£200.00
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MOG(35-55) acid Mouse, Rat 25mg

£250.00
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Catalogue number crb1000205
Sequence (one letter code) MEVGWYRSPFSRVVHLYRNGK-acid
Sequence (three letter code) H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
Research Area Multiple Sclerosis
Purity >95%
Storage -20°C
Molecular Weight 2581.95
Citations S. Sriskantharajah et al. (2014). J Immunol. 192(8): 3518–3529. PMC3979668. K. Cook et al.(2015). Front Microbiol. 6:52. PMC4327743. S. Zandee et al. (2017) Immunology and Cell Biology. 95, 484-490. PMID: 28169287.
Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.

MOG contains one extracellular domain, one transmembrane domain, one cytoplasmic loop, a membrane-associated region, and a cytoplasmic tail. It has been suggested that MOG may function as a cell surface receptor or cell adhesion molecule. Fifteen different alternatively spliced isoforms have been detected in humans which are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or can be found in a secreted form.

The secreted form of MOG could have important effects in triggering autoimmunity if released into the cerebrospinal fluid and then drained into the periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases and is therefore widely studied in this field.

The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing MS like symptoms in animal models. Contains a free carboxylic acid at the C-terminal