Neuromedin U 8 YFLFRPRN-amide


C-terminal peptide from Neuromedin U a neuropeptide involved in cell signalling that mediates a plethora of physiological processes

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Catalogue number crb1001583
Sequence (one letter code) YFLFRPRN-amide
Sequence (three letter code) H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
Research Area Cell Biology
Purity >95%
Molecular Weight 1110.6

Gambone et al., (2011). The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesis. Blood117(21): 5733. PMID: 21378276


Moriyama et al., (2006). The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. Am J Physiol Lung Cell Mol Physiol. 290(5):L971-7. PMID: 16373672

Neuromedin U (NmU) is a neuropeptide expressed in various organs including the brain, gut, bone marrow and lungs. NmU has a wide range of roles in physiology including: decreasing appetite and body weight and increasing gross locomotor activity, heat production, oxygen consumption, uterine smooth muscle contraction, body temperature, and bone mass. It is also involved in regulating circadian rhythm, stress response and blood flow and ion transport in the gut. NmU can also stimulate cytokine production and promote mast cell-mediated inflammation and is important during the early proliferative stages of erythroid development. NmU has been shown to be a c-Myb target gene and NmU in turn activates protein kinase C-βII, a factor associated with hematopoietic differentiation-proliferation.

Two related G protein–coupled receptors have been identified as NmU receptors: NMU-R1: expressed in various tissues, including the small intestine and lung, and NMU-R2: predominantly expressed in the hypothalamus and the small intestine. Activation of these receptors via NmU binding mobilises intracellular Ca2+ stores and downstream signalling.

Neuromedin U 8

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