Ghrelin Human GSS(n-octanoyl)FLSPEHQRVQQRKESKKPPAKLQPR-acid

Description

Hormone produced in stomach, involved in stress response; immunity and glucose metabolism

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Catalogue number crb1000252
Sequence (one letter code) GSS(n-octanoyl)FLSPEHQRVQQRKESKKPPAKLQPR-acid
Sequence (three letter code) H-Gly-Ser-Ser(2-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
Research Area Diabetes, Neurodegenerative diseases (Alzheimer), Obesity
Purity >95%
Molecular Weight 3370.86
References

Colldén, G., Tschöp, M. and Müller, T. (2017). Therapeutic Potential of Targeting the Ghrelin Pathway.  Int J Mol Sci, 18(4), 798. PMID: 28398233

Edwards, A. and Abizaid, A. (2017). Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. Int J Mol Sci, 18(4), 859. PMID: 28422060

Pereira, J., Silva, F. and de Moraes-Vieira, P. (2017). The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. J Diabetes Res, 2017, 1-15. PMID: 29082258

Ghrelin is a peptide hormone mainly produced in the stomach. Ghrelin is involved in several physiological processes, including: feeding and lipid accumulation; stress response; anxiety; cardiac performance; immunity and inflammation; taste sensation; reward-seeking behaviour; regulation of glucose metabolism and thermogenesis; memory; motivation and learning.


Ghrelin exerts its actions by binding the growth hormone secretagogue receptor (GHSR) which is found largely in the hypothalamic and mesolimbic brain regions as well as in peripheral organs (adipose tissue, adrenals, stomach).


Ghrelin is produced by the cleavage of the precursor peptide preproghrelin. The attachment of a fatty acid to its serine 3 residue produces a form capable of activating GHSR.


Gherlin is considered a valuable target for the treatment of conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.

Ghrelin Human

Cat No. Pack Size Price Qty

crb1000252h

0.5mg

$225.00

crb1000252j

1mg

$300.00