Hormone produced in stomach, involved in stress response; immunity and glucose metabolism

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Catalogue number crb1000252
Sequence (one letter code) GSS(n-octanoyl)FLSPEHQRVQQRKESKKPPAKLQPR-acid
Sequence (three letter code) H-Gly-Ser-Ser(2-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
Research Area Diabetes, Neurodegenerative diseases (Alzheimer), Obesity
Purity >95%
Molecular Weight 3370.86

Colldén et al (2017) Therapeutic Potential of Targeting the Ghrelin Pathway.  Int. J. Mol. Sci. 18(4) 798 PMID: 28398233

Edwards and Abizaid (2017) Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. Int. J. Mol. Sci. 18(4) 859 PMID: 28422060

Pereira et al (2017) The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. J. Diabetes Res. 2017 1 PMID: 29082258

Ghrelin is a peptide hormone mainly produced in the stomach. Ghrelin is involved in several physiological processes, including: feeding and lipid accumulation; stress response; anxiety; cardiac performance; immunity and inflammation; taste sensation; reward-seeking behaviour; regulation of glucose metabolism and thermogenesis; memory; motivation and learning.

Ghrelin exerts its actions by binding the growth hormone secretagogue receptor (GHSR) which is found largely in the hypothalamic and mesolimbic brain regions as well as in peripheral organs (adipose tissue, adrenals, stomach).

Ghrelin is produced by the cleavage of the precursor peptide preproghrelin. The attachment of a fatty acid to its serine 3 residue produces a form capable of activating GHSR.

Gherlin is considered a valuable target for the treatment of conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.

Ghrelin Human

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