Kisspeptin 10 mouse, rat Heavy YNWNSFG-[U-13C6,15N-Leu]-RY-amide


Most potent member of the kisspeptin family. Involved in placental development and implantation. Leucine residue labelled with 13C and 15N stable isotopes

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Catalogue number crb1300291
Sequence (one letter code) YNWNSFG-[U-13C6,15N-Leu]-RY-amide
Sequence (three letter code) H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-[U-13C6,15N-Leu]-ArgTyr-NH2
Modifications The C-terminal tyrosine is amidated
Aliases kp-10, KP10, IUPHAR/BPS id; 3711, Metastin (110 - 119) rat, mouse
Research Area Cancer
Purity >95%
Storage -20°C
Molecular Weight 1324.6

Javanmard and Golzar (2015) The Effects of kisspeptin-10 on Migration and Proliferation of Endothelial Cell. Adv. Biomed. Res. 4(1) 41 PMID: 25789267

De Bond and Smith (2014) Kisspeptin and energy balance in reproduction. Reproduction 147(3) R53 PMID: 24327738

Uenoyama et al (2016) The roles of kisspeptin revisited: inside and outside the hypothalamus. J. Reprod. Dev. 62(6) 537 PMID: 27478063

The biologically active C-terminal region of mouse/rat Kisspeptin, with the leucine residue at position 8 of this peptide isotopically labelled with carbon-13 and nitrogen-15, giving a mass increase of 7 compared to the unlabelled peptide.

Kisspeptin, is cleaved from a 145 amino acid precursor to a 54 amino acid peptide in humans and a 52 amino acid peptide in mice. Smaller isoforms of 14, 13 and 10 amino acids have also been isolated, each sharing the common C-terminal sequence. Kisspeptin-10 (KP-10) is the most potent member of the kisspeptin family and the plasma half-life of is approximately 6 fold shorter than KP-54. KP-10 is produced by the trophoblast cells in the first trimester of pregnancy and inhibits cell migration of primary trophoblasts which is essential for placental invasion.

Kisspeptin, a product of the KISS1 gene, is a hypothalamic neuropeptide that stimulates gonadotropin-releasing hormone (GNRH) neurons and drives fertility. Kisspeptin binds specifically to the G-protein-coupled receptor-54, now known as Kiss1r, which is expressed in almost all GNRH neurons. Kiss1r is also expressed in other areas of the brain and periphery, highlighting other possible roles for kisspeptin outside of reproduction

Kisspeptin 10 mouse, rat Heavy

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