PAR-2 Agonist amide X-F-[Cha]-[Cha]-RKPNDK-amide


Thrombin antagonist peptide based on the tethered ligand sequence of PAR-2

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Catalogue number crb1000569
Sequence (one letter code) X-F-[Cha]-[Cha]-RKPNDK-amide
Sequence (three letter code) 3-Mercaptopropionyl-Phe-[Cha]-[Cha]-Arg-Lys-Pro-Asn-Asp-Lys-NH2, , where X-OH is 3-mercaptopropionic acid, where Cha is cyclohexyl-L-alanine
Aliases PAR-2 agonist
Purity >95%
Storage -20°C
Molecular Weight 1297.7

Zhang, H., Zeng, X. and He, S. (2014). Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation. Mediators Inflamm, 2014, 1-20. PMID: 24876677

Moffatt, J. D., Jeffrey, K. L. and Cocks, T. M. (2002). Protease-Activated Receptor-2 Activating Peptide SLIGRL Inhibits Bacterial Lipopolysaccharide-Induced Recruitment of Polymorphonuclear Leukocytes into the Airways of Mice. Am J. Respir Cell Mol Biol, 2002, 26: 680–684

Thrombin receptor inhibitory peptide (TRIP). Thrombin activates members of the PAR family of receptors to initiate a variety of signalling pathways.

Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. This peptide mimics the tethered peptide ligand of PAR- 2, but lacks the S42 residue which is important for receptor activation, and therefore acts as a thrombin antagonist peptide

PAR-2 Agonist amide

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