PAR-3 Agonist (Mouse) SFNGGP-amide


Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-2 agonist peptide mimics the sequence of the “tethered ligand” and is therefore capable of activating the receptor independently of N-terminal proteolysis.

PAR-3 is required for intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells and PAR-3 cooperates with PAR-1 to mediate the effect of thrombin on cytokine production and vascular cell adhesion molecule (VCAM-) 1 expression.

PAR activation has been linked to inflammation, therefore compounds that mimic or interfere with the PAR-activating processes are attractive therapeutic candidates

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Catalogue number crb1000561
Sequence (one letter code) SFNGGP-amide
Sequence (three letter code) H-Ser-Phe-Asn-Gly-Gly-Pro-NH2
Purity >95%
Molecular Weight 576.3

Zhang, H., Zeng, X. and He, S. (2014). Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation. Mediators Inflamm, 2014, 1-20. PMID: 24876677

Representing the activating sequence of the “tethered ligand” of protease cleaved mouse PAR-3.

PAR-3 Agonist (Mouse)

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