PAR-4 Agonist (Human) GYPGQV-amide

Description

Representing the “tethered ligand” domain of protease cleaved human PAR-4.

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Catalogue number crb1000558
Sequence (one letter code) GYPGQV-amide
Sequence (three letter code) H-Gly-Tyr-Pro-Gly-Gln-Val-NH2
Purity >95%
Molecular Weight 618.3
References

Zhang, H., Zeng, X. and He, S. (2014). Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation. Mediators Inflamm, 2014, 1-20. PMID: 24876677

French, S. and Hamilton, J. (2016). Protease-activated receptor 4: from structure to function and back again. Br J Pharmacol, 173(20), 2952-2965. PMID: 26844674

Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-4 agonist peptide represents the N-terminal sequence of the “tethered ligand” and is therefore capable of activating the receptor independently of N-terminal proteolysis

PAR-4 Agonist (Human)

Cat No. Pack Size Price Qty

crb1000558h

0.5mg

$75.00

crb1000558j

1mg

$112.50

crb1000558k

5mg

$150.00