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Zhang, H., Zeng, X. and He, S. (2014). Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation. Mediators Inflamm, 2014, 1-20. PMID: 24876677
French, S. and Hamilton, J. (2016). Protease-activated receptor 4: from structure to function and back again. Br J Pharmacol, 173(20), 2952-2965. PMID: 26844674
Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-4 agonist peptide represents the N-terminal sequence of the “tethered ligand” and is therefore capable of activating the receptor independently of N-terminal proteolysis
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