Peptide5 VDCFLSRPTEKT-acid

Description

Connexin43 mimetic peptide which can reduce swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Reduces mechanical pain hypersensitivity by specifically targeting the NLRP3 inflammasome in the spinal cord. Possesses analgesic effects in mouse neuropathic pain models.

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Catalogue number crb1001430
Sequence (one letter code) VDCFLSRPTEKT-acid
Sequence (three letter code) H-Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr-OH
Disease Area Pain
Research Area Gap junctions, neuroscience, inflammasome
Purity >95%
Storage -20°C
Molecular Weight 1394.7
References

Tonkin et al (2017) Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol. 300 1 PMID: 29055716

Connexin43 mimetic peptide which can reduce swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Reduces mechanical pain hypersensitivity by specifically targeting the NLRP3 inflammasome in the spinal cord. Possesses analgesic effects in mouse neuropathic pain models.

Peptide5

Cat No. Pack Size Price Qty

crb1001430h

0.5mg

$112.50

crb1001430j

1mg

$150.00