Protein-Protein Interactions

Protein–protein interactions (PPIs) are recognised to play a central role in many biological pathways and processes. While many proteins perform their functions independently, the vast majority interact with others for proper biological activity with many molecular activities within a cell carried out by molecular machines that are built from a large number of protein components and organized by their protein-protein interactions.

Important protein-protein interactions are found with chaperone proteins, heat shock proteins, microtubules, transcription factors, immune checkpoint proteins and cytokines. There are currently more than 400,000 known PPIs, and these interactions make up the interactomics of the organism, known as the interacterome.

Aberrant protein-protein interactions are associated with several human diseases, notably those associated with epigenetics, immunology and cancer, and are also are the basis of multiple aggregation-related diseases, such as Creutzfeldt–Jakob and Alzheimer's disease.