ACTH (1-17) Human SYSMEHFRWGKPVGKKR-acid

Description

Fragment of human adrenocorticotropic hormone, a tropic hormone produced and secreted by the anterior pituitary gland.

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Catalogue number crb1000074
Sequence (one letter code) SYSMEHFRWGKPVGKKR-acid
Sequence (three letter code) H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-OH
Purity >95%
Storage - 20 ° C
Molecular Weight 2093.42
References

Ghaddhab et al (2017) From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective. Front. Endocrinol. (Lausanne) 8 PMID: 28228747

Iwayama et al (2018) Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review. BMC Endocr. Disord. 18(1) PMID: 29587720

Kapas et al (1996) Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137(8) 3291 PMID: 8754753

Amino acids 1-17 of human adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a tropic hormone produced and secreted by the anterior pituitary gland and member of the melanocortins peptide family. ACTH is cleaved from the precursor proopiomelanocortin (POMC). ACTH is an important component of the hypothalamic-pituitary-adrenal (HPA) axis and is often produced in response to biological stress. ACTH acts to increase the production and release of cortisol via its interaction with the ACTH receptor; ACTHR, also known as melanocortin type 2 receptor (MC2R). Receptor activation increases the intracellular concentration of cAMP via adenylyl cyclase.


Abnormal ACTH levels in the body has been linked to primary adrenal insufficiency/Addison's disease, Cushing's disease and secondary adrenal insufficiency.

ACTH (1-17) Human

Cat No. Pack Size Price Qty

crb1000074h

0.5mg

$112.50

crb1000074j

1mg

$150.00