PNAClamps are unique probes that facilitate the detection of mutated DNA sequences amongst wild-type sequences. PNAClamps exploit the strong binding affinity of PNA to its complementary DNA to prevent PCR amplification of wild-type DNA sequences whilst allowing amplification of mutated DNA. [diagram see:]

PNAClamps™ advantages:

1. Easy and simple detection of gene mutations by real-time PCR

2. Robust, consistent, reliable and cost effective

3. Highly specific (0.1-1% mutated DNA can be detected)

4. Only small quantity of DNA sample is required (10-50 ng)

5. Compatible with various real-time PCR machines

6. Save time and effort as same protocol works for all PNAClamps

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