Pyroglutamyl β-Amyloid (4-14) Biotin [Pyr]-FRHDSGYEVHH-Biotin

Description

Pyroglutamyl β-Amyloid (4-14) Biotin is derived from Amyloid-β, which has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer’s disease (AD) and Down’s syndrome (DS).

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Catalogue number crb1001104
Sequence (one letter code) [Pyr]-FRHDSGYEVHH-Biotin
Sequence (three letter code) [Pyr]-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Biotin
Modifications biotin is C-terminally linked to the peptide via ethylenediamine, and [Pyr] is pyroglutamic acid
Purity >95%
Storage -20°C
Molecular Weight 1761.8
References

Masters and Selkoe (2012) Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease. Cold Spring Harb. Perspect. Med. 2(6) a006262 PMID: 22675658

Portelius et al (2012). Amyloid-β1-15/16 as a Marker for γ-Secretase Inhibition in Alzheimer's Disease. J. Alzheimer's Disease 31(2) 335 PMID: 22531418 

Selkoe and Hardy (2016) The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8(6) 595 PMID: 27025652

Pyroglutamyl β-Amyloid (4-14) Biotin is derived from Amyloid-β, which has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer’s disease (AD) and Down’s syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.


Aβ is formed from the cleavage of the large, transmembrane protein; APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.


This peptide contains a C-terminal Biotin tag that is covalently bonded via ethylenediamine and can be used for detection and purification. Addionally, there is a Pyroglutamyl molecule located at the N-terminal position.

Pyroglutamyl β-Amyloid (4-14) Biotin

Cat No. Pack Size Price Qty

crb1001104h

0.5mg

$127.50

crb1001104j

1mg

$165.00