gp91 ds-TAT YGRKKRRQRRRCSTRIRRQL-amide

Description

The gp91 ds-TAT peptide is composed of a gp91phox sequence conjugated to the human immunodeficiency virus-TAT peptide. The TAT sequence facilitates its entry into all cells, hence it is a cell-penetrating peptide.

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Catalogue number crb1001119
Sequence (one letter code) YGRKKRRQRRRCSTRIRRQL-amide
Sequence (three letter code) H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Ser-Thr-Arg-Ile-Arg-Arg-Gln-Leu-NH2
Purity >95%
Storage -20°C
Molecular Weight 2671.6
References

Walker et al (2014) Gp91ds-tat, a selective NADPH oxidase peptide inhibitor, increases blood nitric oxide bioavailability in hind limb ischemia and reperfusion. The FASEB J. 28(1)

The gp91 ds-TAT peptide is composed of a gp91phox sequence conjugated to the human immunodeficiency virus-TAT peptide. The TAT sequence facilitates its entry into all cells, hence it is a cell-penetrating peptide.
The gp91 peptide is the haem binding sub-unit of the superoxide-generating NADPH oxidase. As a result, the gp91 ds-TAT peptide can be used as a selective inhibitor of NADPH oxidase assembly.
Recent studies have shown that gp91 ds-TAT can increase blood nitric oxide bioavailability in hind limb ischaemia and reperfusion by inhibiting NADPH oxidase.

gp91 ds-TAT

Cat No. Pack Size Price Qty

crb1001119h

0.5mg

$112.50

crb1001119j

1mg

$150.00