SMAC/DIABLO -TAT (48-60)-[Lys] AVPIAQKPGRKKRRQRRRPPQK-acid

Description

SMAC/DIABLO -TAT (48-60)-[Lys] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). The TAT (48-60) is present to facilitate the delivery of Beclin Scrambled across the plasma membrane.

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Catalogue number crb1000573
Sequence (one letter code) AVPIAQKPGRKKRRQRRRPPQK-acid
Sequence (three letter code) H-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-Lys-OH
Purity >95%
Storage -20°C
Molecular Weight 2650.6
References

Adrain et al (2001). Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. PMID: 1172649

Silke et al (2013). Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation. Cold Spring Harb Perspect Biol. PMID: 23378585

Anguiano-Hernandez et al (2007). Smac/DIABLO and colon cancer. Anticancer Agents Med Chem. PMID: 17630921

SMAC/DIABLO -TAT (48-60)-[Lys] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). During apoptosis the mitochondria has increased permeability to Smac/DIABLO, which causes the protein to diffuse into the cytosol. Here, Smac/DIABLO adheres to Inhibitors of apoptosis proteins (IAPs) and prevents them from binding to caspases, which in turn accentuates apoptosis.


TAT (48-60) is present due to its properties as a cell penetrating cationic peptide (CPP). It derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). As a CPP, TAT (48-60) is able facilitate the delivery of the Beclin scrambled protein across the plasma membrane.


This peptide has an additional lysine attached to the C-terminus of the TAT (48-60) sequence.

SMAC/DIABLO -TAT (48-60)-[Lys]

Cat No. Pack Size Price Qty

crb1000573h

0.5mg

$112.50

crb1000573j

1mg

$150.00