Biotin SBP1 Biotin-[PEG4]-IEEQAKTFLDKFNHEAEDLFYQS-amide

Description

Fragment of the ACE2 peptidase domain (PD) α1 helix, a domain important for the interaction of ACE2 with the SARS coronavirus receptor binding domain (SARS-CoV-2-RBD). Peptide contains a covalently bonded N-terminal Biotin tag and a polyethylene glycol spacer (PEG4).

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Catalogue number crb1001497
Sequence (one letter code) Biotin-[PEG4]-IEEQAKTFLDKFNHEAEDLFYQS-amide
Sequence (three letter code) Biotin-[PEG4]-Ile-Glu-Glu-Gln-Ala-Lys-Thr-Phe-Leu-Asp-Lys-Phe-Asn-His-Glu-Ala-Glu-Asp-Leu-Phe- Tyr-Gln-Ser-NH2
Modifications where PEG4 is polyethylene glycol and acts as a hydrophillic spacer
Purity >95%
Storage -20°C
References

Zhang et al (2020). The first-in-class peptide binder to the SARS-CoV-2 spike protein. bioRxiv preprint March 20. https://www.biorxiv.org/content/10.1101/2020.03.19.999318v1

Fragment of the angiotensin-converting enzyme 2 (ACE2) peptidase domain (PD) α1 helix, a domain important for the interaction of ACE2 with the severe acute respiratory syndrome (SARS coronavirus receptor binding domain (SARS-CoV-2-RBD). SBP1 associates with the SARS-CoV-2-RBD with nanomolar affinity and can potentially block the key mechanism by which SARS CoV-2 initiates entry into human cells.

This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains a polyethylene glycol spacer (PEG4).

Biotin SBP1

Cat No. Pack Size Price Qty

crb1001497h

0.5mg

$112.50

crb1001497j

1mg

$150.00