MOG (35-55) amide Mouse, Rat MEVGWYRSPFSRVVHLYRNGK-amide

Description

Immunoglobulin (Ig) superfamily protein expressed in the central nervous system capable of inducing MS like symptoms in animal models

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Catalogue number crb1000379
Sequence (one letter code) MEVGWYRSPFSRVVHLYRNGK-amide
Sequence (three letter code) H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-NH2
Purity >95%
Storage -20°C
Molecular Weight 2579.3
Citations Sriskantharajah et al (2014) J. Immunol. 192(8) 3518 PMC3979668.

Cook et al (2015) Front. Microbiol. 6 52 PMC4327743

Zandee et al (2017) Immunol. Cell Biol. 95 484 PMID: 28169287.
References

Peschl et al (2017) Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases. Front. Immunol. 8 PMID: 28533781

Weber et al (2018) Defining distinct features of anti-MOG antibody associated central nervous system demyelination. Ther. Adv. Neurol. Disord. 11 175628641876208 PMID: 29623106

Peschl et al (2017) Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination. J. Neuroinflammation 14(1) PMID: 29070051

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system (CNS) on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.


MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.  MOG may function as a cell surface receptor or cell adhesion molecule.  Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.


The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for auto-antibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.


The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has an uncharged C-terminal amide

MOG (35-55) amide Mouse, Rat

Cat No. Pack Size Price Qty

crb1000379h

0.5mg

$165.00

crb1000379j

1mg

$210.00

crb1000379k

5mg

$330.00

crb1000379m

10mg

$405.00

crb1000379n

25mg

$480.00