Biologically active metabolite of Ang-(1-7) labelled with 13C and 15N stable isotopes
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Yu et al (2016) Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor. Peptides 86 33 PMID: 27660028
Angiotensin 1-5 (Ang- (1-5)) is a biologically active metabolite of Ang-(1-7). Its production is catalysed by angiotensin-converting enzyme (ACE). Like Ang-(1-7), Ang-(1-5) stimulates atrial natriuretic peptide (ANP) secretion via the G-protein-coupled receptor, Mas.
The valine residue at position 3 and the isoleucine residue at position 5 of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (2), giving this peptide a mass increase of 13 compared to the unlabelled peptide
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