Angiotensin 1-7 dual Heavy DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-HP-acid

Description

Component of the RAS, opposes actions of Ang-II. Contains 13C and 15N labelled valine and isoleucine residue.

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Catalogue number crb1300303
Sequence (one letter code) DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-HP-acid
Sequence (three letter code) H-Asp-Arg-[U-13C5,15N-Val]-Tyr-[U-13C6,15N-Ile]-His-Pro-OH
Purity >95%
Storage -20°C
Molecular Weight 911.5
References

Santos, S. and Andrade, J. (2014). Angiotensin 1–7: A peptide for preventing and treating metabolic syndrome. Peptides, 59, 34-41. PMID: 25017239

Karnik, S., Singh, K., Tirupula, K. and Unal, H. (2017). Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22. Br J Pharmacol, 174(9), 737-753. PMID: 28194766

Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang-(1‑7) directly from angiotensin I (Ang-I).


Ang-(1-7) broadly opposes Ang-II actions. Ang-(1–7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang‑(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.


The valine residue at position 3 and the isoleucine residue at position 5 of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (2), giving this peptide a mass increase of 13 compared to the unlabelled peptide

Angiotensin 1-7 dual Heavy

Cat No. Pack Size Price Qty

crb1300303c

25nmol

$300.00