Angiotensin II (1-8) DRVYIHPF-acid


Key peptide of the RAS, upregulated in metabolic disorders and some cancers

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Catalogue number crb1000687
Sequence (one letter code) DRVYIHPF-acid
Sequence (three letter code) H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Purity >95%
Storage -20°C
Molecular Weight 1045.5

Azevedo (2014) Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression. PLoS ONE 9(11) e110934 PMID: 25365520

Rodrigues-Ferreira et al (2012) Angiotensin II Facilitates Breast Cancer Cell Migration and Metastasis. PLoS ONE 7(4) e35667 PMID: 22536420

Takane et al (2017) Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure. J. Am. Heart Assoc. 6(4) e004897 PMID: 28428194

Angiotensin II (Ang-II) is a key signalling peptide of the renin angiotensin system (RAS) which is involved in regulating blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and is widely studied in relation to lifestyle-related diseases. 

Ang-II is produced from angiotensinogen (AGT) via the intermediate angiotensin I (Ang-I). AGT is cleaved by the aspartyl-protease, renin, to produce Ang-I, which is then cleaved by the dicarboxyl-peptidase angiotensin converting enzyme (ACE). ACE removes a histidine and a leucine from the C-terminus of Ang-I to form Ang-II.

Ang-II exerts its affect by binding to the G-protein-coupled receptors; Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors. Ang-II plays central roles in glucose metabolism and blood pressure. Increased levels of Ang-II have also been associated with Alzheimer’s disease, and certain cancers including oesophageal squamous cell carcinoma (ESCC), brain cancers and breast cancers. The effects of Ang-II appear to be supressed by another branch of the RAS; the ACE2/Ang-(1-7)/Mas pathway

Angiotensin II (1-8)

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