Angiotensin III RVYIHPF-acid


Member of the RAS, produced from Ang-II by aspartyl aminopeptidase A (APA) and glutamyl APA

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Catalogue number crb1000238
CAS 12687-?51-?3
Sequence (one letter code) RVYIHPF-acid
Sequence (three letter code) H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Purity >95%
Molecular Weight 931.09

Kopf, P. and Campbell, W. (2013). Endothelial Metabolism of Angiotensin II to Angiotensin III, not Angiotensin (1–7), Augments the Vasorelaxation Response in Adrenal Cortical Arteries. Endocrinology, 154(12), 4768-4776. PMID: 24092640

Park, B., Gao, S., Cha, S., Park, B. and Kim, S. (2013). Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels. Physiol Rep, 1(6), e00151. PMID: 24400153

Aspartyl aminopeptidase A (APA) and glutamyl APA, produce angiotensin III (Ang-III) by removing an aspartic acid from the N-terminal of angiotensin-II (Ang-II). Ang-III has many similar biological properties to Ang-II including aldosterone secretion and vasoconstriction, however some of its functions oppose those of Ang-II, such as sodium excretion and secretion of atrial natriuretic peptide (ANP). Due to its ability to promote ANP secretion Ang-III has some cardio protective effects.

Ang-III likely binds to both G-protein-coupled Ang-II type 1 (AT1) and Ang-II type 2 (AT2) receptors with a similar affinity to that of Ang-II. Ang-III appears to be cleared from the plasma at a faster rate than Ang-II, therefore the physiological effects of Ang-III are likely to limited to the site at which it is produced

Angiotensin III

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