Farnesylated a-factor YIIKGVFWDPAC(Farnesyl)-OMe

Description

Farnesylated a-factor is a post-translationally modified mating pheromone derived from Saccharomyces cerevisiae. The addition of a farnesyl group to the C-terminus is crucial for the biological activity of the a-factor.

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Catalogue number crb1001360
Sequence (one letter code) YIIKGVFWDPAC(Farnesyl)-OMe
Sequence (three letter code) Tyr-Ile-Ile-Lys-Gly-Val-Phe-Trp-DPAC(Farnesyl)-Ome
Purity >95%
Storage -20°C
Molecular Weight 1628.9
References

Diaz-Rodriguez and Distefano (2017) a-Factor: a chemical biology tool for the study of protein prenylation. Curr. Top Pept. Protein Res. 18 133 PMID: 29706727

Farnesylated a-factor is a post-translationally modified mating pheromone derived from Saccharomyces cerevisiae. The addition of a farnesyl group to the C-terminus is crucial for the biological activity of the a-factor.


During the mating of Saccharomyces cerevisiae, the haploid state of yeast can be either α-type or a-type. Mating pheromones produced by these haploid cells can induce two different cell types to mate. The α-factor is released from α-type cells and bind to the G-protein coupled receptor (GPCR) Ste2p on a-cells, whereas the a-factor is released from a-type cells and binds to the GPCR Ste3p on α-cells.

Farnesylated a-factor

Cat No. Pack Size Price Qty

crb1001360h

Farnesylated a-factor 0.5mg

$127.50

crb1001360j

Farnesylated a-factor 1mg

$165.00