Proteomics Peptides

Proteomics is the large-scale study of proteomes.   The proteome is the entire set of proteins that is produced or modified by an organism or system.  This varies with time and distinct requirements or stresses that a cell or organism undergoes.  It covers the exploration of proteomes from the overall level of protein composition, structure, and activity. The proteome is not constant but differs from cell to cell and changes over time.  It is an important component of functional genomics. 

Protein activity is modulated by many factors in addition to the expression level of the relevant gene.  Proteins are vital parts of living organisms, with many functions, and proteomics is used to investigate protein expression, rates of protein production, degradation, and steady-state abundance, protein modification, the movement of proteins in cells, their involvement in metabolic pathways and which proteins are involved in biological processes.

 Multiple methods exist to investigate proteomes. The most commonly applied are mass spectrometry based techniques such as Tandem-MS and gel-based techniques such as differential in-gel electrophoresis.

 

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