PTP1B Substrate DADE-[pTyr]-LIPQQG-acid


Substrate peptide for protein tyrosine phosphatase 1B (PTP1B)

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Catalogue number crb1000746
Sequence (one letter code) DADE-[pTyr]-LIPQQG-acid
Sequence (three letter code) H-Asp-Ala-Asp-Glu-[pTyr]-Leu-Ile-Pro-Gln-Gln-Gly-OH
Aliases EGF Receptor Substrate 2
Purity >95%
Storage -20°C
Molecular Weight 1327.5
Citations Fearnley, G. et al (2019). The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion. eLife, 8. doi:10.7554/eLife.44597.001

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M., Murray, G., Mody, N., Neel, B., Bence, K., Wilson, H. and Delibegović, M. (2017). Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. Cancer Res, 78(1), 75-87. PMID: 29122767

Tsou, R., Zimmer, D., De Jonghe, B. and Bence, K. (2012). Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice. Endocrinology, 153(9), 4227-4237. PMID: 22802463

Substrate peptide for protein tyrosine phosphatase 1B (PTP1B); an ubiquitously expressed non-receptor tyrosine phosphatase. PTP1B negatively regulates signalling pathways controlling metabolic homeostasis, cell proliferation and immunity (such as leptin and insulin receptor signalling), making PTP1B an interesting target for type 2 diabetes mellitus (T2DM) and obesity treatment. PTP1B also has important leptin-independent metabolic effects, playing a critical role in the regulation of inflammation, cell proliferation, differentiation and invasion. Therefore PTP1B is also interesting as a therapeutic target for inflammatory and autoimmune diseases and cancer. For application data please see: 10.7554/eLife.44597.005 Figure 2 supplement 1C.

PTP1B Substrate

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