Ubiquitin K11 Heavy TLTG-[K(GG)]-TITLEVEPSDTIENV-[13C6 15N2-Lys] -acid


Sequence corresponding to the bond between Lys-11 side-chain linked mammalian ubiquitin proteins. Contains lysine residue labelled with 13C and 15N isotopes.

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Catalogue number crb1300808
Sequence (one letter code) TLTG-[K(GG)]-TITLEVEPSDTIENV-[13C6 15N2-Lys] -acid
Sequence (three letter code) H-Thr-Leu-Thr-Gly-[Lys(Gly-Gly)]-Thr-Ile-Thr-Leu-Glu-Val-Glu-Pro-Ser-Asp-Thr-Ile-Glu-Asn-Val-OH
Purity >95%
Storage -20°C
Molecular Weight 2409.3

Bremm and Komander (2011) Emerging roles for Lys11-linked polyubiquitin in cellular regulation. Trends Biochem. Sci. 36(7) 355 PMID: 21641804

Locke et al (2014) Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation. Biochem. J. 459(1) 205 PMID: 21641804

Swatek and Komander (2016) Ubiquitin modifications. Cell Res. 26(4) 399 PMID: 27012465

This sequence corresponds to the peptide bond between mammalian Lys11- (K11) linked Ub proteins; where (GG) corresponds to the C-terminus of the side chain appended Ub.
Chains containing Lys11 (K11) Ub linkages are considered atypical. However they have been implicated in a range of cellular pathways. K11-Linked Ub, assembled via the ubiquitin ligase: anaphase-promoting complex/cyclosome (APC/C), regulate cell cycle progression via targeting proteins to the proteasome. K11 ubiquitin linkages are also involved in maintaining endoplasmic reticulum homeostasis and maintaining cellular protein homeostasis and have been discovered in protein aggregates found in neurodegenerative diseases, such as Alzheimer’s disease and Huntington’s disease.

The C-terminal lysine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.

Ubiquitin K11 Heavy

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