Ubiquitin K11 Light TLTG-[K(GG)]-TITLEVEPSDTIENVK-acid


Sequence corresponding to the bond between Lys11 side-chain linked mammalian ubiquitin proteins

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Catalogue number crb1000807
Sequence (one letter code) TLTG-[K(GG)]-TITLEVEPSDTIENVK-acid
Sequence (three letter code) H-Thr-Leu-Thr-Gly-[Lys(Gly-Gly)-Thr-Ile-Thr-Leu-Glu-Val-Glu-Pro-Ser-Asp-Thr-Ile-Glu- Asn-Val-Lys-OH
Purity >95%
Storage -20°C
Molecular Weight 2401.3
References Bremm, A. and Komander, D. (2011). Emerging roles for Lys11-linked polyubiquitin in cellular regulation. Trends Biochem Sci. 36(7):355-63 PMID: 21641804 Locke, M., Toth, J. and Petroski, M. (2014). Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation. Biochem J, 459(1), 205-216. PMID: 21641804 Swatek, K. and Komander, D. (2016). Ubiquitin modifications. Cell Res, 26(4), 399-422. PMID: 27012465
This sequence corresponds to the peptide bond between mammalian Lys11- (K11) linked Ub proteins; where (GG) corresponds to the C-terminus of the side chain appended Ub.

Chains containing Lys11 (K11) Ub linkages are considered atypical. However they have been implicated in a range of cellular pathways. K11-Linked Ub, assembled via the ubiquitin ligase: anaphase-promoting complex/cyclosome (APC/C), regulate cell cycle progression via targeting proteins to the proteasome. K11 ubiquitin linkages are also involved in maintaining endoplasmic reticulum homeostasis and maintaining cellular protein homeostasis and have been discovered in protein aggregates found in neurodegenerative diseases, such as Alzheimer’s disease and Huntington’s disease.

Ubiquitin K11 Light

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