PTH (1-34) Heavy SVSEIQ-[U-13C6,15N-Leu]-MHN-[U-13C6,15N-Leu]-GKH-[U-13C6,15N-Leu]-NSMERVE-W-[U-13C6,15N-Leu]-RKKLQDVHNF-acid


Biologically active peptide fragment of parathyroid hormone (PTH) with multiple leucine residues labelled with stable 13C and 15N isotopes

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Catalogue number crb1300439
Sequence (one letter code) SVSEIQ-[U-13C6,15N-Leu]-MHN-[U-13C6,15N-Leu]-GKH-[U-13C6,15N-Leu]-NSMERVE-W-[U-13C6,15N-Leu]-RKKLQDVHNF-acid
Sequence (three letter code) H-Ser-Val-Ser-Glu-Ile-Gln-[U-13C6,15N-Leu]-Met-His-Asn-[U-13C6,15N-Leu]-Gly-Lys-His-[U-13C6,15N-Leu]-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-[U-13C6,15N-Leu]-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
Aliases Parathyroid Hormone 1-34, hPTH (1-34), Teriparatide
Purity >95%
Storage -20°C
Molecular Weight 4143.2

Lee, D., Southgate, R., Farhat, Y., Loiselle, A., Hammert, W., Awad, H. and O'Keefe, R. (2014). Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. J Orthop Res, 33(1), 17-24. PMID: 25266795

Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D., Tsiaoussis, J., Spandidos, D., Tsatsakis, A. and Tzanakakis, G. (2016). Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncol Rep, 36(4), 1787-1792. PMID: 27499459

PTH 1-34, is a biologically active peptide fragment of parathyroid hormone (PTH). PHT 1-34 has been shown to enhance bone fracture healing by promoting osteogenesis. PTH 1-34 also has chondrogenic properties.

PTH is an 84-amino-acid polypeptide hormone (PTH 1-84) which is secreted by the parathyroid glands along with its fragments (such as PTH 1-34 and PTH 7-84). PTH increases calcium and decrease phosphate levels in the blood and the abundance of PTH-derived peptides is regulated by blood calcium levels. PTH inhibits the bone growth-promoting activity of osteoblasts and induces osteoclasts to resorb bone and release calcium and phosphate ions into the blood. PTH binds to and activates the receptor parathyroid hormone receptor 1 (PTHR1). PTHR1 is a G-protein-coupled receptor (GPCR) which regulates mineral ion homeostasis, bone turnover and skeletal development.

The leucine residues at positions 7, 11, 15, and 24 of this peptide are isotopically labelled with carbon-13 (25) and nitrogen-15 (4), giving this peptide a mass increase of 28 compared to the unlabelled peptide

PTH (1-34) Heavy

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